Scientist I, Synthetic Biology Job at Generate Biomedicines, Somerville, MA

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  • Generate Biomedicines
  • Somerville, MA

Job Description

Generate Biomedicines seeks a Scientist in Synthetic Biology to develop pooled screening workflows for testing hundreds of thousands of protein variants in parallel. The role combines DNA library design, protein display technology, and NGS analysis to identify protein binders and modulators, with collaboration across protein sciences and machine learning teams.

Responsibilities

  • Design and implement pooled screening workflows from assay setup through data interpretation
  • Establish assay conditions, quantitative measures, and protocols for project team adoption
  • Evaluate novel hypotheses and unconventional approaches to support drug program acceleration
  • Synthesize experimental findings into recommendations and present across disciplines
  • Apply quantitative reasoning and literature review to guide experimental design decisions

Requirements

  • Strong experimental background in synthetic biology and pooled screening techniques
  • Proficiency in DNA library design and next-generation sequencing analysis
  • Experience with in vitro protein display or similar high-throughput assay methods
  • Quantitative reasoning and comfort with computational or statistical analysis
  • One position requires mammalian cell engineering and membrane protein expertise
  • Ability to communicate findings clearly to interdisciplinary teams

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